Overlap of genetic influences in phenotypes classically categorized as psychiatric vs medical disorders

Table 2 Over-represented disease annotation for systems biology model

Disease	Percent of network genes annotated (%)	P value
Ovarian neoplasms	76.74	5.80E-29
Ovarian diseases	76.74	3.24E-27
Adnexal diseases	76.74	3.89E-27
Mesothelioma	48.84	2.04E-26
Neoplasms, mesothelial	48.84	2.50E-26
Gonadal disorders	76.74	4.23E-26
Genital neoplasms, female	79.07	8.70E-26
Hyperoxia	30.23	2.10E-23
Genital diseases, female	83.72	4.75E-22
Astrocytoma	72.09	4.82E-22
Neoplasms, connective and soft tissue	62.79	1.64E-21
Glioblastoma	69.77	3.67E-21

The 43 genes in the GeneGo model developed from the 6 candidate genes show significant over-representation for cancers, especially hormone sensitive cancers, and brain diseases, including brain cancers. P values characterizing the significance of enrichment are calculated within the GeneGo software based on a hypergeometric distribution.