Clinical research in febrile neutropenia in cancer patients: Past achievements and perspectives for the future

doi:10.5495/wjcid.v6.i3.37

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World Journal of Clinical Infectious Diseases

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2220-3176

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Infect Dis. Aug 25, 2016; 6(3): 37-60
Published online Aug 25, 2016. doi: 10.5495/wjcid.v6.i3.37

Table 8 Usual sensitivity and resistances of fungi against the different antifungals[149-151]

Antifungal classes	Antifungal agent	Common resistances	Common sensitivity
Polyenes	Amphotericine B:	Candida lusitaniae	Candida
	Deoxycolate	Trichosporon	Aspergillus
	Liposomal	Fusarium	Zygomycetes
	Lipid complex	Scedosporium
	Colloidal dispersion	Aspergillus terreus
	5 Fluorocytosine	Zygomycetes	Candida
		Scedosporium	Torulopsis
		Fusarium	T. glabrata
		Cryptococcus	Cryptococcus
		Candida	Phialophora
			Cliadosporium
			Exophiala
Triazoles	Fluconazoles	Aspergillus	Candida albicans and others
		Candida kruzei	Candida glabrata¹
		Candida glabrata	Cryptococcus neoformans
		Zygomycetes	Blastomyces dermatitidis
			Coccidioides
			Histoplasma capsulatum
	Itraconazole	Aspergillus niger	As itraconazole + Aspergillus flavus
		Aspergilus terreus	Aspergillus fumigatus
		Zygomycetes	Candida kruzei
		Mucor	Trichophyton
		Fusarium solani
		Penicillium
	Voriconazole	Zygomycetes	As itraconazole + Aspergillus niger
		Sisyrinchium inflatum	Aspergillus tereus
		Fusarium oxysporum, penicillium, Schedosporium apiospermum
	Posaconazole	Trichosporon asahii	As voriconazole + Trichophyton
			Zygomycetes
Echinocandins	Caspofungin	Cryptococcus
	Micafungin	Zygomycetes
	Anidulafungin	Fusarium
		Paecilomyces lilacinus
		Trichosporon
		Schedosporium
		prolificans
		Schedosporium inflatum
		Candida parapsilosis

¹Are not always sensible to the antifungals.

Citation: Klastersky J, Paesmans M, Aoun M, Georgala A, Loizidou A, Lalami Y, Dal Lago L. Clinical research in febrile neutropenia in cancer patients: Past achievements and perspectives for the future. World J Clin Infect Dis 2016; 6(3): 37-60
URL: https://www.wjgnet.com/2220-3176/full/v6/i3/37.htm
DOI: https://dx.doi.org/10.5495/wjcid.v6.i3.37