DNA methylation in liver diseases

doi:10.5495/wjcid.v4.i4.41

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Nov 25, 2014 (publication date) through Dec 2, 2024

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World Journal of Clinical Infectious Diseases

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2220-3176

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Infect Dis. Nov 25, 2014; 4(4): 41-49
Published online Nov 25, 2014. doi: 10.5495/wjcid.v4.i4.41

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Figure 3 The maintenance of DNA methylation pattern. A: In somatic cells, DNA methyltransferase (DNMT) 3 (DNMT 3a and DNMT 3b) are bound to nucleosomes containing methylated DNA; B: During DNA semi-reserved replication, DNMT1 interact with the DNA polymerase processing factor proliferating cell nuclear antigen (PCNA) and ubiquitin-like plant homeodomain and RiNG finger domain containing protein 1 (UHRF1) and methylate the hemimethylated sites; C: Soon after DNA semi-reserved replication, DNMT3 correct methylation sites missed by DNMT1 and complete the process.

Citation: Gao S, Wang K. DNA methylation in liver diseases. World J Clin Infect Dis 2014; 4(4): 41-49
URL: https://www.wjgnet.com/2220-3176/full/v4/i4/41.htm
DOI: https://dx.doi.org/10.5495/wjcid.v4.i4.41