Transcribing virulence in Staphylococcus aureus

Figure 2 Post-transcriptional regulation of SigB. After stress-induction, RsbU de-phosphorylates RsbV, which can then bind specifically to RsbW thereby removing RsbW from SigB. Phosphorylated RsbV is inactive and therefore cannot bind RsbW. RsbW also promotes phosphorylation of RsbV to maintain its inactivity. RsbW binds to SigB to inhibit transcription by preventing SigB from complexing with the RNA polymerase (RNAP). Once SigB is free from inhibition by RsbW, it can complex with RNAP forming the holoenzyme and activate transcription of target genes. Active proteins are highlighted with yellow.