Pathogenesis of Chagas disease cardiomyopathy

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Jun 25, 2012 (publication date) through Dec 1, 2024

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World Journal of Clinical Infectious Diseases

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2220-3176

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Infect Dis. Jun 25, 2012; 2(3): 39-53
Published online Jun 25, 2012. doi: 10.5495/wjcid.v2.i3.39

Table 2 Cytokine and chemokine expression in Chagas disease and animal models

Cytokines/chemokines	Phase (acute/chronic/IND/severe/moderate CCC)	Host (mouse/human)	Organ/cell type	Reference
IFN-γ	Severe CCC	Human	Mononuclear cells	[54,56]
IFN-γ	Severe CCC	Human	Myocardium	[60,61]
IFN-γ	Severe CCC	Human	Heart-infiltrating T cells	[54]
IFN-γ	IND, Severe CCC	Human	Plasma	[52,54,55]
TNF-α	Severe CCC	Human	Mononuclear cells	[54, 56]
TNF-α	Severe CCC	Human	Heart-infiltrating T cells	[54]
TNF-α	Severe CCC	Human	Myocardium	[60, 61]
TNF-α	IND and Severe CCC	Human	Plasma	[52,54,55]
IFN-γ	Acute/chronic	Mouse	Heart	[121-123]
TNF-α	Acute/chronic	Mouse	Heart	[124]
IL-6	Severe CCC	Human	HEART-infiltrating T cells	[54,60,61]
IL-2	Severe CCC	Human	Heart-infiltrating T cells	[54,60,61]
IL-4	Severe CCC	Human	Heart-infiltrating T cells	[54,60,61]
IL-10	Severe CCC	Human	Heart-infiltrating T cells	[54,60,61]
IL-7	Severe CCC	Human	Myocardium	[62]
IL-15	Severe CCC	Human	Myocardium	[62]
IL-12	Acute	Mouse	Mononuclear cells	[125]
IL-18	Acute	Mouse	Mononuclear cells	[126]
IL-10	Acute	Mouse	Mononuclear cells	[44-46]
TGF-β	Acute	Mouse	Mononuclear cells	[44-46]
IL-17	Chronic	Mouse	Mononuclear cells	[47]
CCL2, CXCL10, CXCL9 (mRNA)	Severe CCC	Human	Myocardium	[59]
CCR2, CXCR3 (mRNA)	Severe CCC	Human	Myocardium	[59]
CCR5, CXCR3	Severe CCC, IND	Human	Mononuclear cells	[63]
CCL5, CXCL9, CXCL10	Chronic	Mouse	Cardiomyocytes	[127]
CCR5	Chronic	Mouse	Heart	[40,128]
CCL5, CCL4, CXCR3 (mRNA)	Chronic	Dog	Heart	[41]

CCC: Chronic Chagas disease cardiomyopathy; IND: Indeterminate clinical form; IFN: Interferon; TNF: Tumor necrosis factor; IL: Interleukin.

Citation: Teixeira PC, Frade AF, Nogueira LG, Kalil J, Chevillard C, Cunha-Neto E. Pathogenesis of Chagas disease cardiomyopathy. World J Clin Infect Dis 2012; 2(3): 39-53
URL: https://www.wjgnet.com/2220-3176/full/v2/i3/39.htm
DOI: https://dx.doi.org/10.5495/wjcid.v2.i3.39