Pathogenesis of Chagas disease cardiomyopathy

Table 1 Molecular mimicry after Trypanosoma cruzi infection

Host component	T. cruzi antigen	Host	Molecular definition
Neurons, liver, Kidney, testis	?	M, R	Mab
Neurons	Sulphated glycolipids	H, R	Mab, sera
47 kDa neuron protein	FL 160	H, R	rDNA, AS
Heart and skeletal muscle	Microsomal fraction	H, M	Mab, Serum IgG
Smooth and striated muscle	150 kDa protein	H, M	Serum IgG
Human cardiac Myosin heavy chain	B13 protein	H	rDNA, Ab T cell clones
Human cardiac myosin heavy chain	Cruzipain	M	Ab
95 KDa myosin tail	T. cruzi cytoskeleton	M	Mab
Skeletal muscle Ca++ dependent SRA	SRA	H, Rb	AS, serum IgG
Glycosphingolipids	Glycosphingolipids	H, M	Serum IgG
MAP (brain)	MAP	H, M	rDNA, AS
Myelin basic protein	T. cruzi soluble extract	M	Serum IgG, T cells
28 kDa lymphocyte membrane protein	55 kDa membrane protein	H, M	Mab
23 kDa ribosomal protein	23 kDa ribosomal protein	H	Ab
Ribosomal P protein	Ribosomal P protein	H	rDNA, Ab, SP
38-kDa heart antigen	R13 peptide from ribosomal protein P1, P2	M	IgG1, IgG2
β1 adrenoreceptor M2 muscarinic receptor	Ribosomal P0 and P2 proteins	H	Ab, SP
β1-adrenoreceptor M2 cholinergic receptor	150 kDa protein	H, M	Mab
Cardiac muscarinic Acetylcholine receptors (mAChR)	?	H	Ab
Cardiac muscarinic Acetylcholine receptors (mAChR)	Cruzipain	M	Immunization with cruzipain
Cha antigen	SAPA, 36KDa TENU2845	M	Ab, T cells

M: Mouse; H: Human; Rb: Rabbit; R: Rat; AS; Antiserum; Ab: Patient antibody; Mab: Monoclonal antibody; rDNA: Recombinant DNA; SP: Synthetic peptides (adapted from Bilate and Cunha-Neto[6] and Cunha-Neto et al[120]). SRA: Cross-reacting antigen; MAP: Microtubule associated protein. T. Cruzi: Trypanosoma cruzi.