Statins as antifungal agents

doi:10.5495/wjcid.v1.i1.4

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World Journal of Clinical Infectious Diseases

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2220-3176

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Infect Dis. Dec 30, 2011; 1(1): 4-10
Published online Dec 30, 2011. doi: 10.5495/wjcid.v1.i1.4

Table 4 Revealed in vitro interactions between statins and non-antifungal drugs against zygomycetous fungi

Species	Non-antifungal drug	Statin	Interaction	Ref.
Zygomycetes
Absidia corymbifera	SUR	FLV	SYN	[35]
Absidia glauca	SUR	FLV	ANT	[35]
Micromucor ramanniana	SUR	FLV	SYN	[35]
Mucor circinelloides f. lusitanicus	SUR	FLV	ADD, SYN	[35]
Mucor racemosus	SUR	FLV	ANT	[35]
Mycotypha africana	PAF	ATO, SIM	ADD	[34]
		LOV, ROS	ADD, SYN	[34]
Rhizomucor mieheii	SUR	FLV	ANT	[35]
Rhizomucor pusillus	SUR	FLV	ANT	[35]
Rhizopus oryzae	SUR	FLV	ADD, SYN	[35]
Rhizopus schipperae	SUR	FLV	ADD, SYN	[35]
Saksanaea vasiformis	SUR	FLV	ADD, SYN	[35]
Syncephalastrum racemosum	PAF	ATO	ADD, SYN	[34]
		ROS, SIM	SYN	[34]
	SUR	FLV	ADD, SYN	[35]

ADD: Additive interaction; ANT: Antagonism; ATO: Atorvastatin; FLV: Fluvastatin; LOV: Lovastatin; PAF: Penicillium chrysogenum antifungal protein; ROS: Rosuvastatin; SIM: Simvastatin; SUR: Suramin; SYN: Synergistic interaction.

Citation: Galgóczy L, Nyilasi I, Papp T, Vágvölgyi C. Statins as antifungal agents. World J Clin Infect Dis 2011; 1(1): 4-10
URL: https://www.wjgnet.com/2220-3176/full/v1/i1/4.htm
DOI: https://dx.doi.org/10.5495/wjcid.v1.i1.4