Loss of cavin1 and expression of p-caveolin-1 in pulmonary hypertension: Possible role in neointima formation

Figure 3 Double immunofluorescence study showing the expression of cav-1 (green) and smooth muscle α-actin (red) in pulmonary arteries from control (C), Monocrotaline (MCT, M), H (hypoxia) and MCT + hypoxia (M+H) groups. A: Arteries (size 95-111 μm) from C and H depict well preserved cav-1 expression in the endothelial layer and no evidence of enhanced expression of cav-1 in SMC. Artery from M shows significant loss of endothelial cav-1; and the artery from M+H shows complete loss of endothelial cav-1 and enhanced expression of cav-1 in SMC; B: Arteries (size 21-41 μm) from C and H show well preserved endothelial cav-1 and the absence of enhanced expression of cav-1 in SMC. The arteries from both M and M+H show loss of endothelial cav-1 and enhanced expression of cav-1 in SMC and almost occluded lumen in the M+H.