Copyright
©The Author(s) 2017.
World J Hypertens. May 23, 2017; 7(2): 24-31
Published online May 23, 2017. doi: 10.5494/wjh.v7.i2.24
Published online May 23, 2017. doi: 10.5494/wjh.v7.i2.24
Table 2 Allele and genotype frequencies of GNB3 in the gender/age sub-categories
| Male | Female | |||||
| Cases n (%) | Controls n (%) | P-value1 | Cases n (%) | Controls n (%) | P-value1 | |
| Age ≤ 49 yr | ||||||
| Allele | ||||||
| C825 (wild) | 350 (44.9) | 1433 (50.4) | 0.007 | 244 (47.7) | 2912 (49.9) | 0.33 |
| T825 (variant) | 430 (55.1) | 1413 (49.6) | 268 (52.3) | 2922 (50.1) | ||
| Genotype | ||||||
| CC | 85 (21.8) | 356 (25.0) | 0.008 | 60 (23.4) | 718 (24.6) | 0.5 |
| CT | 180 (46.2) | 721 (50.7) | 124 (48.4) | 1476 (50.6) | ||
| TT | 125 (32.1) | 346 (24.3) | 72 (28.1) | 723 (24.8) | ||
| HWE | χ² = 1.76, P = 0.19 | χ² = 0.26, P = 0.61 | χ² = 0.22, P = 0.64 | χ² = 0.42, P = 0.52 | ||
| Age ≥ 50 yr | ||||||
| Allele | ||||||
| C825 (wild) | 903 (48.8) | 1649 (49.2) | 0.78 | 1229 (50.1) | 2175 (49.5) | 0.63 |
| T825 (variant) | 947 (51.2) | 1701 (50.8) | 1223 (49.9) | 2217 (50.5) | ||
| Genotype | ||||||
| CC | 221 (23.9) | 412 (24.6) | 0.92 | 309 (25.2) | 537 (24.5) | 0.88 |
| CT | 461 (49.8) | 825 (49.3) | 611 (49.8) | 1101 (50.1) | ||
| TT | 243 (26.3) | 438 (26.1) | 306 (25.0) | 558 (25.4) | ||
| HWE | χ² = 0.01, P = 0.94 | χ² = 0.36, P = 0.55 | χ² = 0.01, P = 0.91 | χ² = 0.02, P = 0.89 | ||
- Citation: Eto M, Takeshima T, Harada M, Fujiwara S, Kumada M, Kamesaki T, Takamura K, Kenzaka T, Nakamura Y, Aonuma T, Okayama M, Kajii E. Association between G-protein β3 subunit gene and isolated systolic blood pressure elevation of greater than 130 mmHg: A large-scale cross-sectional study in the Japanese population. World J Hypertens 2017; 7(2): 24-31
- URL: https://www.wjgnet.com/2220-3168/full/v7/i2/24.htm
- DOI: https://dx.doi.org/10.5494/wjh.v7.i2.24