Role of adipocytes in hypertension

Figure 4 Small adipocytes release anti-inflammatory agents such as adiponectin, interleukin 10, and interleukin 1 receptor antagonist. Hypertrophy of small adipocytes into large adipocytes changes the biochemical release products, into inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor alpha (TNFα), and monocyte chemotactic protein 1 (MCP1)] and other chemicals such as leptin and angiotensin II that contribute to the disease. Increased activation of the sympathetic nervous system also contributes. IL-10: Interleukin-10; IL-1R: Interleukin 1 receptor; Myf5: Myogenic factor 5; Pax 7: Paired box protein 7; Pax 3: Paired box protein 3; ROS: Reactive oxygen species.