Management of hypertension: Current state of the art and challenges

Table 2 Drugs to be preferred in patients with special conditions

Comorbidity	First-line therapy
Ischemic heart disease	β-blocker (unless contraindicated) Long-acting calcium channel blocker ACE inhibitors (ARBs if ACE inhibitors not tolerated)
Heart failure	ACE inhibitors (ARBs if ACE inhibitors not tolerated) β-blockers Aldosterone antagonists
Diabetes	ACE inhibitors (ARBs if ACE inhibitors not tolerated) β-blockers Calcium channel blockers
Chronic kidney disease	ACE inhibitors or ARBs Loop diuretics rather than a thiazide diuretic (or combination)
Stroke	Diuretic + ACE inhibitors
Asymptomatic organ damage
Left ventricular hypertrophy	ACE inhibitors, ARBs, Calcium channel blockers
Proteinuria	ACE inhibitors, ARBs

ACE: Angiotensin converting enzyme; ARBs: Angiotensin II receptor blockers.