Regression of cardiovascular remodeling in hypertension: Novel relevant mechanisms

doi:10.5494/wjh.v6.i1.1

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World Journal of Hypertension

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2220-3168

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hypertens. Feb 23, 2016; 6(1): 1-17
Published online Feb 23, 2016. doi: 10.5494/wjh.v6.i1.1

Table 1 Rho kinase downstream target proteins, some signaling pathways and cellular functions[8]

ROCK downstreamtarget protein	Signaling pathway	Function
Myosin binding subunit of MLC/MYPT1	MYPT1/MLC	Stress fiber formation
MLC2	MYPT1/MLC2	Mediates calcium sensitization and thereby enhances and sustains contraction in the vascular bed
LIM kinase/cofilin	LIM kinase/cofilin	Stress fiber formation
Ezrin/radixin/moesin
Adducin

ROCK: Rho kinase; MLC: Myosin light chain; MYPT1: Myosin phosphatase target subunit 1.

Citation: Jalil JE, Ocaranza MP. Regression of cardiovascular remodeling in hypertension: Novel relevant mechanisms. World J Hypertens 2016; 6(1): 1-17
URL: https://www.wjgnet.com/2220-3168/full/v6/i1/1.htm
DOI: https://dx.doi.org/10.5494/wjh.v6.i1.1