Symplicity-3 hypertension trial: Basic and clinical insights

Figure 2 The use of high frequency electrical stimulation applied to the left ganglionated plexi in a patient with atrial fibrillation induced a marked slowing of the ventricular rate by a parasympathetic response at the A-V node. The ensuing heart block manifested an asystolic pause of 4300 milliseconds (ms) which showed a rapid recovery with the cessation of electrical stimulation. The traces from above are: Leads III and aVL of the electrocardiogram; an electrogram recorded from the right ventricle (RV); and arterial blood pressure. GP: Ganglionated plexi; HFS: High-frequency stimulation.