Adipose tissue dysfunction and the pathogenesis of metabolic syndrome

Figure 2 The role of adipose tissue dysfunction in the pathogenesis of metabolic syndrome. The mechanisms of metabolic syndrome are just as the base of iceberg under the sea level, such as insulin resistance, adipose tissue dysfunction, inflammation, and oxidative stress, etc. The relative clinical manifestations are as the top part of iceberg above the sea level, including hypertension, obesity, type 2 diabetes mellitus or impaired glucose tolerance, dyslipidemia, etc.