Induction of tissue angiotensin II-forming activity in two-kidney, one-clip hypertensive hamster model

Figure 4 Aortic tissue angiotensin II-forming activity in two-kidney, one-clip hypertensive hamsters. Aortic tissue (A) total, (B) chymase-, (C) angiotensin (Ang) converting enzyme (ACE)-, and (D) other enzyme-dependent Ang II-forming activities in sham-operated and two-kidney, one-clip (2K1C) hypertensive hamsters. Hamster aortas were removed, and activities were measured at 18 wk after clipping either without or with ACE inhibitor (ACE-I) (Temocapril; 30 mg/kg per day) or angiotensin II type 1 receptor antagonist (ARB) (CS866; 10 mg/kg per day) treatment. Results are presented as means ± SEM’s; n = 6 per group. ^aP < 0.05; ^bP < 0.1 vs Vehicle; ^cP < 0.05 vs Sham.