Induction of tissue angiotensin II-forming activity in two-kidney, one-clip hypertensive hamster model

Figure 2 Chymase and angiotensin converting enzyme mRNA expressions and localization of mast cell in two-kidney, one-clip hamsters. Time course for changes in chymase and angiotensin converting enzyme (ACE) mRNA expression in the heart, aorta, and lung in sham-operated and two-kidney, one-clip (2K1C) hamsters. Chymase mRNA expression in (A) heart, (C) aorta, and (E) lung. ACE mRNA expression in (B) heart, (D) aorta, and (F) lung. Photomicrograph of the same section stained by toluidine blue shows the heart and the ascending aorta from sham-operated (G, I) and 2K1C (H, J) hamster. Mast cells identified by toluidine blue staining (arrowheads) appear in epicardium of the heart (G, H) and adventitia of the aorta (I, J). Results are presented as means ± SEM; n = 5-6 per group. ^aP < 0.05 vs Sham.