Induction of tissue angiotensin II-forming activity in two-kidney, one-clip hypertensive hamster model

Figure 1 Blood pressures and heart weights of hypertensive hamsters. Time course for changes in noninvasively measured systolic blood pressure in two-kidney, one-clip (2K1C) hypertensive hamsters. Either an angiotensin (Ang) converting enzyme inhibitor (ACE-I), an Ang II type 1 receptor antagonist (ARB), or saline was administered, beginning at 2 wk after renal artery clipping; n = 6-8 for each time point. A: Hamster hearts were removed and weighed at 18 wk after clipping, n = 6 per group; B: Results are presented as means ± SEMs. ^bP < 0.01, ^aP < 0.05 vs Vehicle; ^dP < 0.01 vs Sham.