Oxidative stress-mediated effects of angiotensin II in the cardiovascular system

doi:10.5494/wjh.v2.i4.34

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Aug 23, 2012 (publication date) through Nov 15, 2024

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World Journal of Hypertension

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2220-3168

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hypertens. Aug 23, 2012; 2(4): 34-44
Published online Aug 23, 2012. doi: 10.5494/wjh.v2.i4.34

Table 1 Reactive oxygen species signaling pathways and Ang II-induced cardiovascular diseases

Disease	Receptor(s)	NAD(P)H oxidase	ROS	CaMKII	Other signaling molecules	Ref.
Arrhythmias	AT₁R/AT₂R	+ (Nox2)	+	+	Ca²⁺ handing, RyR, I_Ca,L, I_Na, I_NCX	[23,71,74-85]
Cell death/heart failure	AT₁R ?	+ (p47^phox)	+	+	p38MARK	[70,88-90]
I/R injury	AT₁R/AT₂R	+	+	?	Rac1 GTPase	[91-98]
Hypertrophy	AT₁R	+	+	+, ?	Transcription factors	[67,103-113]
Hypertension	AT₁R	+ (p22^phox)	+	+	Nitric oxide	[114-122]

+: Involved; ?: Not clear; AT₁R: Ang II type 1 receptor; AT₂R: Ang II type 2 receptor; RyR: Ryanodine receptor; I_Ca,L: L-type calcium current; I_Na: Sodium current; I_NCX: Sodium-calcium exchange current; p38MARK: p38 mitogen-activated protein kinase.

Citation: Wen H, Gwathmey JK, Xie LH. Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. World J Hypertens 2012; 2(4): 34-44
URL: https://www.wjgnet.com/2220-3168/full/v2/i4/34.htm
DOI: https://dx.doi.org/10.5494/wjh.v2.i4.34