Oxidative stress-mediated effects of angiotensin II in the cardiovascular system

doi:10.5494/wjh.v2.i4.34

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 2, Issue 4

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7915)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-1) series.

Item

Count

PDF

625

HTML

6834

Figures (1-1)

267

Tables (1-1)

189

Sum=7915

Aug 23, 2012 (publication date) through Jul 15, 2024

Times Cited of This Article

Times Cited (73)

Journal Information of This Article

Publication Name

World Journal of Hypertension

ISSN

2220-3168

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Hypertens. Aug 23, 2012; 2(4): 34-44
Published online Aug 23, 2012. doi: 10.5494/wjh.v2.i4.34

Table 1 Reactive oxygen species signaling pathways and Ang II-induced cardiovascular diseases

Disease	Receptor(s)	NAD(P)H oxidase	ROS	CaMKII	Other signaling molecules	Ref.
Arrhythmias	AT₁R/AT₂R	+ (Nox2)	+	+	Ca²⁺ handing, RyR, I_Ca,L, I_Na, I_NCX	[23,71,74-85]
Cell death/heart failure	AT₁R ?	+ (p47^phox)	+	+	p38MARK	[70,88-90]
I/R injury	AT₁R/AT₂R	+	+	?	Rac1 GTPase	[91-98]
Hypertrophy	AT₁R	+	+	+, ?	Transcription factors	[67,103-113]
Hypertension	AT₁R	+ (p22^phox)	+	+	Nitric oxide	[114-122]

+: Involved; ?: Not clear; AT₁R: Ang II type 1 receptor; AT₂R: Ang II type 2 receptor; RyR: Ryanodine receptor; I_Ca,L: L-type calcium current; I_Na: Sodium current; I_NCX: Sodium-calcium exchange current; p38MARK: p38 mitogen-activated protein kinase.

Citation: Wen H, Gwathmey JK, Xie LH. Oxidative stress-mediated effects of angiotensin II in the cardiovascular system. World J Hypertens 2012; 2(4): 34-44
URL: https://www.wjgnet.com/2220-3168/full/v2/i4/34.htm
DOI: https://dx.doi.org/10.5494/wjh.v2.i4.34