Environmental mineral density and thyroid malignancy: A multicenter cross-sectional study

Table 7 Sociodemographic, clinical and ultrasonographic features associated with malignancy in thyroid nodules

Variables	Univariate analysis		Multivariate analysis
	P value	OR (95%CI)	P value	Adjusted OR (95%CI)
Age (years)
≤ 20		1		1
21-60	0.319	1.52 (0.67-3.46)	0.614	1.32 (0.26-2.24)
> 60	0.003	2.81 (1.37-5.78)	0.025	2.81 (1.14-6.94)
Province of origin of the sample
South Kivu		1		1
Kinshasa	0.212	1.76 (0.72-4.29)	0.116	2.47 (0.80-7.62)
Katanga	0.014	4.93 (1.39-17.54)	0.036	8.19 (1.14-12.45)
Family history of thyroid pathology
No		1		1
Yes	0.022	1.63 (1.03-2.59)	0.105	1.65 (0.90-3.34)
Clinical LAD
No		1		1
Yes	< 0.001	10.55 (5.40-20.62)	0.760	1.20 (0.38-3.82)
Echostructure
Liquid		1		1
Solid	< 0.001	15.21 (5.50-42.07)	0.001	7.69 (2.40-24.58)
Echogenicity
Isoechoic		1		1
Hypoechoic	< 0.001	18.72 (3.95-28.68)	0.017	14.19 (1.60-25.93)
Size
Micronodule		1		1
Macronodule	< 0.001	5.33 (2.75-10.33)	< 0.001	9.13 (4.19-19.89)
Calcification
No		1		1
Yes	< 0.001	5.72 (3.42-9.55)	0.017	2.60 (1.19-5.70)
Sonographic LAD
No		1		1
Yes	< 0.001	10.74 (6.36-18.13)	< 0.000	6.94 (2.79-17.25)

LAD: Lymphadenopathy; OR: Odds ratio.