Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models

Figure 7 Inhibition of molecular targets by GO-Y030 in vivo. A: HE stains of the control group treated with DMSO alone. The inset indicates a closer magnified view; B: HE stains of IOMM-Lee treated with GO-Y030. The inset indicates a more detailed view. Pyknotic cell nuclei are observed; C: Immunohistochemistry (IHC) of N-Cadherin (N-Cad) in the control group; D: IHC of N-Cad in IOMM-Lee treated with GO-Y030; E: IHC of nuclear factor kappa-B p65 (NF-kB) in the control; F: IHC of the NF-kB of IOMM-Lee treated with GO-Y030; G: IHC of the hepatocellular growth factor (HGF) in the control group; H: IHC of HGF in IOMM-Lee treated with GO-Y030. The red dashed line distinguishes between the cells with intact tumor nuclei that test positive for each molecule, and the cells with pyknotic nuclei that test negative affected with GO-Y030 peripherally from vessels.