Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models

Figure 4 Inhibition of molecular targets in meningioma cell lines (IOMM-Lee) with GO-Y030 in vitro. A: Hematoxylin and eosin (HE) stains of IOMM-Lee treated with DMSO alone (control); B: Immunohistochemistry (IHC) of the N-Cadherin (N-Cad) in the control; C: IHC of the hepatocellular growth factor (HGF) in the control; D: IHC of nuclear factor kappa-B p65 (NF-kB) in the control; E: HE stains of IOMM-Lee treated with GO-Y030 at twice concentration of the 50% inhibitory concentration (IC₅₀ × 2); F: IHC of the N-Cad in IOMM-Lee treated with GO-Y030 at IC₅₀ x 2; G: IHC of NF-kB in IOMM-Lee treated with GO-Y030 at IC₅₀ × 2; H: IHC of the HGF in IOMM-Lee treated with GO-Y030 at IC₅₀ × 2; I: The percentage of normal appearance cells in IOMM-Lee treated with GO-Y030 at IC₅₀ × 2. J: The percentage of positive cells for N-Cad in IOMM-Lee treated with GO-Y030 at IC₅₀ × 2; K: The percentage of positive cells for NF-kB in IOMM-Lee treated with GO-Y030 at IC₅₀ × 2; L: The percentage of positive cells for HGF in IOMM-Lee treated with GO-Y030 at IC₅₀ × 2.