Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models

Figure 3 GO-Y030’s inhibitory effect on meningioma growth in vivo. A: The treatment schedule for the mouse model included intratumor (iT) hepatocellular growth factor administration every 3 days and daily intraperitoneal (ip) administration of GO-Y030; B: Relative tumor volume, with day 1, is set as 100%. GO-Y030 was administered at either 1 mg/kg mouse weight or 2 mg/kg indicated in orange or grey, respectively. The control was indicated in blue. Notably, GO-Y030 significantly suppressed tumor growth. ^aP and ^bP indicate the P values between the control and 1 mg/kg, and between the control and 2 mg/kg, 0.041 and 0.002, respectively. There was no significance between the 1 mg/kg and 2 mg/kg. ^cP = 0.059. The open circle represents the averages of 5 tumors, and the vertical bar depicts the standard deviation. HGF: Hepatocellular growth factor.