Copyright
©The Author(s) 2024.
World J Exp Med. Dec 20, 2024; 14(4): 96005
Published online Dec 20, 2024. doi: 10.5493/wjem.v14.i4.96005
Published online Dec 20, 2024. doi: 10.5493/wjem.v14.i4.96005
Agent | Target | Combined with | Ref. |
CG-5 | GLUT1 | - | [1] |
Gemcitabine | |||
2-DG | Glycolysis | - | [2] |
Gemcitabine | |||
3-BP | Glycolysis | - | [3] |
BNBZ | HK2 | - | [4] |
PGMI-004A | PGAM1 | - | [4] |
KH3 | PGAM1 | - | [4] |
CPI-613 | PDH | - | [5] |
Galloflavin | |||
Cyano-4-hydroxycinnamic acid | |||
Rotenone | OXPHOS: Complex I | - | [6] |
Metformin | |||
Phenformin | |||
IACS-010759 | |||
Atovaquone | OXPHOS: Bc1 complex | - | [7] |
N-hydroxyindoles | LDHA | - | [8] |
N-hydroxyindole-NHI-1 | Gemcitabine | [8] | |
Galloflavinin | LDHA | Metformin | [9] |
Gossypol | - | [10] | |
FX11 | - | [1] | |
Avasimibe | ACAT1 | - | [11] |
Luteolin | FASN | - | [12] |
C75 | - | [11] | |
Palbociclib | - | [13] | |
Paclitaxel nano-formulation | - | [14] | |
Orlistat | FASN | - | [15] |
Gemcitabine | [1] | ||
EGCG | FASN, GLUD1 & PGAM1 | - | [1,4] |
Lansoprazole | FASN | - | [11] |
Pantoprazole | |||
Rabeprazole | |||
Omeprazole | |||
DEAB | ALDH | - | [16] |
Gemcitabine | |||
Disulfiram | ALDH | [16] | |
A939572 | SCD | - | [17] |
CAY10566 | SCD | - | [18] |
Gemcitabine | |||
SB-204990 | ACLY | - | [11] |
BAY ACC022 | - | ||
TOFA | Fatty acid synthesis | - | [19] |
Silibinin | Lipid metabolism | - | [20,21] |
Atorvastatin, | HMG-CoA reductase | - | [22] |
Lovastatin | |||
Pravastatin | |||
Rosuvastatin | |||
Simvastatin | |||
Etomoxir | FAO | Carnitine palmitoyl transferase I inhibitor | [11] |
Artesunate | Lipid metabolism | [11] | |
Zalcitabine | |||
Avasimin | SOAT1 | [11] | |
Opaganib | SK2 | [23] | |
Vitamin D | Lipid metabolism | [24] | |
DON | Gln | - | [25] |
Sirpiglenastat | Gln | - | [25] |
Trametinib | |||
ss-lapachone | GLS | - | [1] |
Thiazolidine-2,4-dione derivatives | |||
BPTES | GLS | - | [26] |
ß-lapachone (ß-lap) | [27] | ||
968 | GLS | - | [26] |
CB-839 | GLS | - | [26] |
ß-lap | [27] | ||
BSO | |||
BPTES encapsulated nanoparticles | GLS | - | [26] |
Metformin | |||
GPNA | Gln transporter | - | [28] |
ASNase | Asparagine | GCN2iA/B | [29] |
PD-325901 | |||
Indoximod | IDO | - | [30] |
Carbidopa | - | ||
Epacadostat | IDO | - | [27] |
PEG-ADI | Arginine metabolism | - | [23] |
Radiotherapy | [27] | ||
Gemcitabine | |||
Gemcitabine + docetaxel | |||
Panobinostat | |||
SM-88 | Mucin-1 synthesis | - | [23] |
AG-270 | MAT2A | - | [23] |
Taxane-based chemotherapy |
- Citation: Maiti A, Mondal S, Choudhury S, Bandopadhyay A, Mukherjee S, Sikdar N. Oncometabolites in pancreatic cancer: Strategies and its implications. World J Exp Med 2024; 14(4): 96005
- URL: https://www.wjgnet.com/2220-315x/full/v14/i4/96005.htm
- DOI: https://dx.doi.org/10.5493/wjem.v14.i4.96005