Dapagliflozin as an oral antihyperglycemic agent in the management of diabetes mellitus in patients with liver cirrhosis

Table 4 Comparison of clinical and laboratory investigations changes on follow-up in both groups

Parameter	Dapagliflozin, n = 200		Control group, n = 100		Test of sig.
					t	P value
	Mean	SD	Mean	SD
Body weight in kg	11.26	12.12	7.40	21.56	-1.982	0.048
BMI in kg/m2	3.92	4.35	2.54	6.91	-2.103	0.036
SBP in mmHg	0.70	16.77	0.80	15.68	-0.051	0.959
DBP in mmHg	0.73	11.81	0.00	12.55	0.481	0.631
HbA1c as %	2.77	2.03	2.75	1.67	0.072	0.943
Fasting blood sugar in mg/dL	124.52	66.17	82.86	104.24	-4.206	0.000
Triglycerides in mg/dL	13.06	95.16	18.42	54.61	-0.619	0.537
Cholesterol in mg/dL	6.35	74.66	6.56	41.71	-0.032	0.975
Creatinine in mg/dL	0.01	0.55	-0.01	0.32	0.345	0.730
MELD	0.19	5.76	0.14	3.20	0.097	0.923
MELD-Na	0.09	8.48	0.76	3.09	-0.993	0.321
eGFR value in mL/min/1.73 m2	10.96	63.42	19.79	57.57	-1.21	0.228
Uric acid in mg/dL	0.18	1.02	0.00	1.14	1.349	0.179
AST in IU/L	4.71	89.72	6.98	37.89	-0.308	0.758
ALT in IU/L	0.05	32.30	-1.32	23.08	0.422	0.673
GGT in IU/L	0.79	218.46	0.67	167.59	0.005	0.996
Serum Na in mmol/L	0.44	7.50	0.06	4.03	0.563	0.574
Serum K in mg/dL	0.11	0.63	0.14	0.61	-0.379	0.705

ALT: Alanine transaminase; AST: Aspartate aminotransferase; BMI: Body mass index; DBP: Diastolic blood pressure; eGFR: Estimated glomerular filtration rate; GGT: gamma-glutamyl transferase; HbA1c: Hemoglobin A1c; K: Potassium; MELD: Model for end-stage liver disease; MELD-Na: Model for end-stage liver disease-sodium; NA: Sodium; SBP: Systolic blood pressure.