Dapagliflozin as an oral antihyperglycemic agent in the management of diabetes mellitus in patients with liver cirrhosis

Table 2 Comparison of body mass index, blood pressure and laboratory investigations before and after dapagliflozin treatment

Parameter	Dapagliflozin before, n = 200		Dapagliflozin after, n = 200		Test of sig.
	Mean	SD	Mean	SD	t	P value
Body weight in kg	90.58	17.14	83.18	13.22	4.836	0.0001
BMI in kg/m2	31.74	5.24	29.20	4.41	5.251	0.0001
SBP in mmHg	110.18	12.01	109.48	11.62	0.592	0.554
DBP in mmHg	72.30	8.92	71.58	8.66	0.825	0.410
HbA1c as %	9.64	1.74	6.88	1.12	18.906	0.0001
Fasting blood sugar in mg/dL	225.83	92.09	142.98	55.16	10.916	0.0001
Triglycerides in mg/dL	180.46	82.07	167.40	66.19	1.752	0.081
Cholesterol in mg/dL	205.36	58.85	199.02	56.94	1.096	0.274
Creatinine in mg/dL	0.87	0.35	0.86	0.44	0.176	0.860
MELD	11.07	5.09	10.88	5.17	0.37	0.711
MELD-Na	14.40	6.82	14.31	7.06	0.13	0.897
eGFR value in mL/min/1.73 m2	125.93	59.37	116.12	49.50	1.788	0.075
Uric acid in mg/dL	5.07	1.05	4.89	0.85	1.908	0.057
AST in IU/L	49.06	68.16	44.36	61.00	0.727	0.467
ALT in IU/L	30.74	23.73	30.69	24.57	0.021	0.983
GGT in IU/L	78.64	126.52	77.84	185.29	0.05	0.960
Serum Na in mmol/L	133.48	4.77	133.05	5.64	0.832	0.406
Serum K in mg/dL	4.22	0.50	4.10	0.37	2.554	0.011

ALT: Alanine transaminase; AST: Aspartate aminotransferase; BMI: Body mass index; DBP: Diastolic blood pressure; eGFR: Estimated glomerular filtration rate; GGT: gamma-glutamyl transferase; HbA1c: Hemoglobin A1c; K: Potassium; MELD: Model for end-stage liver disease; MELD-Na: Model for end-stage liver disease-sodium; NA: Sodium; SBP: Systolic blood pressure.