Platelet-to-neutrophil ratio predicts hemorrhagic transformation and unfavorable outcomes in acute ischemic stroke with intravenous thrombolysis

doi:10.5493/wjem.v14.i3.95540

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World Journal of Experimental Medicine

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World J Exp Med. Sep 20, 2024; 14(3): 95540
Published online Sep 20, 2024. doi: 10.5493/wjem.v14.i3.95540

Table 4 Clinical characteristics of patients according to presence/absence of delayed neurological deterioration and 3-mo outcome after intravenous recombinant tissue plasminogen activator treatment

Variables	Total, n = 418	No D-ND, n = 182	D-ND, n = 236	P value	Good 3-months, n = 250	Poor 3-months, n = 168	P value
Age in yr	64.5 (53-72)	60 (49-67.25)	67 (58-76.75)	< 0.001¹	60 (50-68)	69 (61-75)	< 0.001¹
Sex
Male	249 (59.6)	120 (65.9)	129 (54.7)	0.02²	162 (64.8)	87 (51.8)	0.008²
Female	169 (40.4)	62 (34.1)	107 (45.3)		88 (35.2)	81 (48.2)
Risk factor
Hypertension	299 (71.5)	114 (62.6)	185 (79.1)	< 0.001²	163 (65.2)	136 (81.9)	< 0.001²
Dyslipidemia	276 (66.0)	113 (62.8)	163 (69.7)	0.141²	162 (65.3)	114 (68.7)	0.478²
Diabetes Mellitus	141 (33.7)	55 (30.4)	86 (36.4)	0.195²	73 (29.3)	68 (40.5)	0.018²
Atrial fibrillation/atrial flutter	102 (24.4)	40 (22.0)	62 (26.3)	0.311²	53 (21.2)	49 (29.2)	0.063²
Old stroke	47 (11.2)	16 (8.8)	31 (13.2)	0.16²	24 (9.7)	23 (13.7)	0.21²
Current smoking	73 (17.5)	38 (86.4)	35 (79.5)	0.395²	52 (85.2)	21 (77.8)	0.39²
Current alcohol drinking	42 (10.0)	20 (95.2)	22 (84.6)	0.24²	30 (88.2)	12 (92.3)	0.685²
Etiology
Other determined or undetermined	177 (42.3)	69 (38.3)	108 (46.0)	0.004²	93 (37.5)	84 (50.3)	0.002²
Cardioembolic	102 (24.4)	51 (28.3)	51 (21.7)		70 (28.2)	32 (19.2)
Small-artery occlusion	94 (22.5)	50 (27.8)	44 (18.7)		66 (26.6)	28 (16.8)
Large-artery atherosclerosis	42(10)	10 (5.6)	32 (13.6)		19 (7.7)	23 (13.8)
Medication
Antihypertensive therapy	202 (45.6)	81 (44.5)	121 (51.3)	0.17²	111 (44.4)	91 (54.2)	0.05²
Antiplatelet therapy	81 (18.3)	31 (17.0)	50 (21.2)	0.287²	44 (17.6)	37 (22.0)	0.262²
Hypoglycemic therapy	121 (27.3)	53 (29.1)	68 (28.9)	0.967²	71 (28.5)	50 (29.8)	0.783²
Infarct volume in mL	3.27 (0.58-24.24)	1.16 (0.05-7.88)	7.61 (1.53-63.41)	0.36¹	1.46 (0.13-7.93)	16.62 (2.51-103.09)	0.013¹
Time for stroke onset to intravenous rtPA infusion in min	170.05 (124-218.25)	182 (0-125)	167.5 (120-219.5)	0.528¹	173.5 (125-218)	166.5 (120-220)	0.306¹

¹Mann Whitney U test.

²χ² test.

Data are n (%)/median (25^th-75^th percentiles). D-ND: Delayed neurological deterioration; rtPA: Recombinant tissue plasminogen activator.

Citation: Chaiwisitkun A, Muengtaweepongsa S. Platelet-to-neutrophil ratio predicts hemorrhagic transformation and unfavorable outcomes in acute ischemic stroke with intravenous thrombolysis. World J Exp Med 2024; 14(3): 95540
URL: https://www.wjgnet.com/2220-315x/full/v14/i3/95540.htm
DOI: https://dx.doi.org/10.5493/wjem.v14.i3.95540