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©The Author(s) 2024.
World J Exp Med. Sep 20, 2024; 14(3): 95540
Published online Sep 20, 2024. doi: 10.5493/wjem.v14.i3.95540
Published online Sep 20, 2024. doi: 10.5493/wjem.v14.i3.95540
Table 3 Clinical characteristics of patients according to presence/absence of early neurological deterioration and hemorrhagic transformation after intravenous recombinant tissue plasminogen activator treatment
Variables | Total, n = 418 | No E-ND, n = 394 | E-ND, n = 24 | P value | No HT, n = 342 | HT, n = 75 | P value |
Age in yr | 64.5 (53-72) | 64 (52-71) | 70 (58.75-77.25) | 0.0451 | 65 (53-72) | 64 (52-74) | 0.9391 |
Sex | |||||||
Male | 249 (59.6) | 237 (60.2) | 12 (50) | 0.3252 | 206 (60.2) | 42 (56.0) | 0.4992 |
Female | 169 (40.4) | 157 (39.8) | 12 (50) | 136 (39.8) | 33 (44.0) | ||
Risk factor | |||||||
Hypertension | 299 (71.5) | 279 (71.2) | 20 (83.3) | 0.1982 | 245 (72.1) | 53 (70.7) | 0.8082 |
Dyslipidemia | 276 (66.0) | 261 (66.9) | 15 (62.5) | 0.6552 | 223 (65.8) | 52 (70.3) | 0.4582 |
Diabetes mellitus | 141 (33.7) | 126 (32.1) | 15 (62.5) | 0.0022 | 114 (33.4) | 26 (34.7) | 0.8382 |
Atrial fibrillation/ atrial flutter | 102 (24.4) | 97 (24.6) | 5 (20.8) | 0.6752 | 81 (23.7) | 21 (28.0) | 0.4312 |
Old stroke | 47 (11.2) | 44 (11.3) | 3 (12.5) | 0.8522 | 44 (13.0) | 3 (4.0) | 0.0272 |
Current smoking | 73 (17.5) | 70 (82.4) | 3 (100) | 0.4242 | 62 (83.8) | 10 (76.9) | 0.5462 |
Current alcohol drinking | 42 (10.0) | 42 (91.3) | 0 (0) | 0.0032 | 37 (90.2) | 5 (83.3) | 0.6082 |
Etiology | |||||||
Other determined or undetermined | 177 (42.3) | 161 (41.2) | 16 (66.7) | 0.0052 | 143 (42.1) | 34 (45.3) | < 0.0012 |
Cardioembolic | 102 (24.4) | 100 (25.6) | 2 (8.3) | 73 (21.5) | 29 (38.7) | ||
Small-artery occlusion | 94 (22.5) | 93 (23.8) | 1 (4.2) | 91 (26.8) | 3 (4.0) | ||
Large-artery atherosclerosis | 42 (10) | 37 (9.5) | 5 (20.8) | 33 (9.7) | 9 (12.0) | ||
Medication | |||||||
Antihypertensive therapy | 202 (45.6) | 75 (19.0) | 6 (25.0) | 0.4732 | 165 (48.2) | 37 (49.3) | 0.8642 |
Antiplatelet therapy | 81 (18.3) | 191 (48.5) | 11 (45.8) | 0.8012 | 63 (18.4) | 18 (24.0) | 0.2692 |
Hypoglycemic therapy | 121 (27.3) | 111 (28.2) | 10 (41.7) | 0.162 | 96 (28.2) | 25 (33.3) | 0.3712 |
Infarct volume in mL | 3.27 (0.58-24.24) | 2.76 (0.45-20.25) | 34.42 (5.57-303.93) | < 0.0011 | 2.67 (0.43-16.88) | 13.99 (1.11-73.07) | 0.3891 |
Time for stroke onset to intravenous rtPA infusion in min | 170.05 (124-218.25) | 170 (122-217) | 180.5 (147.5-232.25) | 0.1571 | 172 (124.85-218.25) | 160 (124-219) | 0.5161 |
- Citation: Chaiwisitkun A, Muengtaweepongsa S. Platelet-to-neutrophil ratio predicts hemorrhagic transformation and unfavorable outcomes in acute ischemic stroke with intravenous thrombolysis. World J Exp Med 2024; 14(3): 95540
- URL: https://www.wjgnet.com/2220-315x/full/v14/i3/95540.htm
- DOI: https://dx.doi.org/10.5493/wjem.v14.i3.95540