Experimental models of high-risk bowel anastomosis in rats: A systematic review

Table 7 Ischaemia/reperfusion models of high-risk anastomosis

Ref.	Year	I/R method	Sample size	Intervention	Test	Sampling day
Terzi et al[110]	2001	SMA clampling 30 min	65	Allopurinol	BPR in situ, macroscopic (adhesions as per Knightly et al[39]), histology (as per de Roy van Zuidewijn et al[54])	3/7
Tireli et al[111]	2003	SMA clampling 30 min	20	Pentoxifiline	BPR ex situ, HP	7
Miranda et al[112]	2010	SMA clamping 45 min	45	Methylene blue	BPR ex situ, macroscopic, histology	7
Celik et al[113]	2013	SMA clamping 45 min	24	Modelukast	BPR ex situ, HP, MPO, MDA, caspase-3 activity, catalase, NOx, glutathione, SOD, TNF-a, IL-6, ALT, AST	5
Akarsu et al[114]	2017	SMA clamping 10 min	40	Simvastatin	BPR ex situ, HP	8
Özkan et al[115]	2018	SMA clamping 30 min	30	Melatonin	BPR ex situ, HP, histology (as per Nursal et al[116]), SOD, glutathione	7
Özçay et al[117]	2018	SMA clamping 45 min	40	GH	Macroscopic (as per Galili et al[118]), BPR ex situ, histology (as per Greenhalgh et al[64])	7
Sayin et al[119]	2020	SMA clamping 45 min	40	IP montelukast	BPR ex situ, macroscopic score (as per Knightly et al[39]), HP, histology (fibrosis)	7
Eryilmaz et al[120]	2020	SMA clamping 45 min	30	Hydrogen rich saline	BPR in situ, histology (as per Park et al[121] and Chiu et al[122]), TNF-a, IL-6, MDA, MPO	5
Akıncı et al[123]	2022	SMA clamping 30 min	36	Genistein	BPR ex situ, HP, SOD, glutathione, histology (as per Piroglu et al[124])	5

SMA: Superior mesenteric artery; GH: Growth hormone; IP: Intra-peritoneal; SOD: Superoxide dismutase; BPR: Bursting pressure; HP: Hydroxyproline; MPO: Myeloperoxidase; MDA: Malondialdehyde; IL: Interleukin; TNF-a: Tumor necrosis factor-alpha; I/R method: Ischaemia/reperfusion method.