Experimental models of high-risk bowel anastomosis in rats: A systematic review

Table 6 Radiation models of high-risk anastomosis

Study	Year	Radiation dose	Sample size	Intervention	Test	Sampling day
Liu et al[101]	2001	10 Gy	74	Lactobacillus plantarum 299v	Body weight, WBC, mucosal MPO, HP, nucleotide, DNA and RNA content, colonic bacterial microflora, bacterial translocation, histology	4/7/11
Kerem et al[102]	2006	500 cGy	84	Soluble Fiber	Macroscopic (adhesions as per van der Ham and Kort[32]), BPR in situ, HP, histology (as per de Roy van Zuidewijn et al[54]), MMP-2 activity	3/7
Ozdemir et al[103]	2013	800 rad	30	Amifostine	BPR ex situ, HP, histology	5
Seker et al[104]	2014	485 cGy	60	Pycnogenol	BPR ex situ, HP, MDA, histology (as per Houdart et al[105])	3/7
Simões Neto et al[106]	2013	660 cGy	30	Fraction electron beam	BPR (not specified), histology	7
Van de Putte et al[107]	2017	27Gy	48	AdMSC	18F-FDG-PET/CT, colonoscopy, histology	32
Taşdöven et al[108]	2019	6Gy	48	Ozon PR	BPR in situ, histology (as per Houdart et al[105]), HP, MDA, MPO	3/7
Yilmaz et al[109]	2022	20Gy	32	Ozon PR	BPR in situ, macroscopic (as per Knightly et al[39]), HP, MPO, histology (as per de Roy van Zuidewijn et al[54])	5

AdMSC: Adipose tissue derived mesenchymal stem cells; PR: Per rectum; MPO: Myeloperoxidase; HP: Hydroxyproline; MMP: Metalloproteases; BPR: Bursting pressure; MDA: Malondialdehyde.