Experimental models of high-risk bowel anastomosis in rats: A systematic review

Table 4 Obstruction models of high-risk anastomosis

Ref.	Year	Obstruction method	Sample size	Intervention	Test	Sampling day
Törnqvist et al[60]	1990	Silicone ring 6.5 mm	54	Diverting colostomy	Tensile strength, weight, HP	2/7
Aguilar-Nascimento et al[61]	1997	Silk ligature	108	Nutritional solutions lavage of the colon	Macroscopic, histology	3/6
Erbil et al[62]	2000	Silk ligature	144	Nutritional solutions lavage of the colon	BPR ex situ, HP, macroscopic	3/6
Cağlikülekçi et al[63]	2002	Common bile duct ligation	40	rGH	BPR ex situ, macroscopic, HP, macroscopic, histology (as per Greenhalgh et al[64])	7
Lelyanov et al[65]	2004	Silk ligature	60	Sodium hypochlorite and ozone therapy	BPR ex situ, survival, macroscopic, histology	1/3/6/9/12
Krarup et al[59]	2017	Laparoscopic clip application	32	MMP inhibition	Body WT, HP, BPR in situ	3

HP: Hydroxyproline; WT: Weight; BPR: Bursting pressure; MMP: Metalloproteases; rGH: Recombinant growth hormone.