Experimental models of high-risk bowel anastomosis in rats: A systematic review

Table 3 Malnutrition models of high-risk anastomosis

Ref.	Year	Colitis method	Sample size	Intervention	Test	Sampling day
McCauley et al[51]	1991	3,5% agar diet for 7 d	30	BCAA	Body WT, BPR ex situ, tensile strength, protein content, HP	-
Karahasanoglu et al[52]	1998	Low-protein diet for 10 d	40	Growth hormone	Body WT, BPR in situ, hydroxyproline	4
Salman et al[53]	2008	15 d	72	Cholerella sp. microalgae	Body WT, macroscopic (adhesions as per Ham et al[32]), BPR in situ, HP, histology (as per de Roy van Zuidewijn et al[54]), albumin, prealbumin, transferrin	3/5/7/9/11/13/15
Gonçalves et al[55]	2009	50% food restriction for 21 d	80	Pre-op nutrition	Tensile strength, histology	5
Gündoğdu et al[56]	2015	50% food restriction for 26 d	18	Pre-op nutrition	Body WT, BPR in situ, HP	4
Vizzotto Junior et al[57]	2015	Paired feeding	160	Omega-3	Body WT, tensile strength, histology	5
Danielski et al[58]	2016	50% food restriction for 26 d	45	Vitamin C	Body WT, macroscopic (as per Knightly et al[39]), histology, HP, MPO, TNF-a, nitrite/nitrate, oxidative damage	7

WT: Weight; BPR: Bursting pressure; HP: Hydroxyproline; TNF-a: Tumor necrosis factor–alpha; MPO: Myeloperoxidase; BCAA: Branch chained amino acids.