Hepatic and renal effects of oral stingless bee honey in a streptozotocin-induced diabetic rat model

Figure 4 H&E staining of liver tissue sample on day 13. A: Tissue sample for the non-diabetic (ND) control group; B: Untreated (UNT) diabetic group; C: Stingless bee honey (SBH) treatment group; D: Metformin (MET) treatment group; E: Stingless bee honey plus metformin (SBME) treatment group. The ND control group showed normal liver architecture. The UNT group had lipid droplet formation in hepatocytes with dilated blood sinusoids and congestion surrounding central veins. The SBH group showed significant reduction in steatosis and sinusoid congestion. The MET group showed a reduction in steatosis, but sinusoids congestion was still present. The SBME group had decreased lipid droplet formation and dilated blood sinusoids (H&E staining, 40 ×). CV: Central vein; BS: Blood sinusoids; H: Hepatocytes; LD: Lipid droplet; DBS: Dilated blood sinusoids.