Understanding wound healing in obesity

Table 2 Animal models used in wound healing, advantages and disadvantages

Animal model	Advantages	Disadvantages
Hypertrophic wound model	Low cost	Hypertrophic scar different from human[27,29]
	Allows for production of hypertrophic scar[28,29]	Requires special device[28,29]
		Labor intensive: Frequent care to maintain tension and device placement[31]
Wound-induced hair follicle neogenesis (WIHN) model	Low cost
	Regeneration following adult wounding with minimal recovery of hair follicles at the scar center[32,48]	High variability: Mouse strains, environmental conditions, age of mice, and wound size)[33]
	Test therapeutics to activate regenerative wound healing[33]	May not translate to human injury[48]
Excisional wound model	Low cost	Labor intensive: Frequent dressing changes to maintain tension[35]
	Wound healing similar to human[35]
	Allows for fibroblast lineage tracing[49]