Differential diagnosis and management of immune checkpoint inhibitor-induced colitis: A comprehensive review

Figure 2 Representative images of infectious colitis (Hematoxylin and eosin). A: Low magnification view of cytomegaloviral (CMV) colitis. Notice the lymphocytes and neutrophils in the lamina propria (100 ×); B: Note an owl-eye inclusion characterized by enlarged nucleus with oval, eosinophilic intranuclear inclusion surrounded by clear halo, consistent with CMV inclusion (400 ×); C: Clostridium difficile colitis. Pseudomembranes composed of fibrin, neutrophils and necrotic epithelial cells are on the surface of the mucosal glands (40 ×). Yellow sign notes a viral inclusiona.