Differential diagnosis and management of immune checkpoint inhibitor-induced colitis: A comprehensive review

Figure 1 Representative images of immune checkpoint inhibitor-induced colitis in a patient with metastatic melanoma treated with nivolumab and ipilimumab for 2 mo (Hematoxylin and eosin). A: Active colitis characterized by mixed inflammatory cell infiltrates in the lamina propria and surface erosion (100 ×); B: High magnification of A. Note the neutrophils, lymphocytes, and plasma cells in the lamina propria (200 ×); C: Active colitis with mild crypt architectural irregularity (100 ×); D: Active colitis with neutrophilic cryptitis (200 ×).