Copyright
©The Author(s) 2021.
World J Exp Med. Nov 20, 2021; 11(5): 55-65
Published online Nov 20, 2021. doi: 10.5493/wjem.v11.i5.55
Published online Nov 20, 2021. doi: 10.5493/wjem.v11.i5.55
Ref. | Biomarker name | Biomarker assay method | Sample size | Rejection type | Sensitivity/ specificity | PPV/NPV | Comments |
Patel et al[56] | CDC crossmatch | Micro-cytotoxicity assay | 225 | Hyper acute rejection/ early graft loss | 0.75/0.97 | 0.80/0.97 | FDA approved |
Mahoney et al[57] | Flow crossmatch | Flow cytometry | 90 | Early graft loss | 0.71/0.74 | 0.33/0.93 | FDA approved |
Pei et al[58] | Luminex | HLA beads; flow cytometry | 10 | Anti HLA Ab | - | - | FDA approved |
Ashokkumar et al[59] | Pleximmune | T cytotoxicmemory cell | 32 | Acute rejection | 0.88/0.94 | 0.93/0.88 | FDA approved |
He et al[60] | Cylex-Immuknow | Lymphocyte ATPgeneration | 42 | CD4 T cell function | - | - | FDA approved |
Loupy et al[61] | C1q bindingassay | Flow cytometric C1q binding | 1016 | TCMR/ABMR/graft loss | - | - | FDA approved |
Hricik et al[62] | IFN-γ ELISPOT | Donor-reactive memory T cell | 21 | De novo DSA/ rejection | 1.0/0.67 | 0.67/1.0 | Not FDA approved |
Roedder et al[63] | KSORT | PBLRNA by qPCR | 143 | AR | 0.83/0.91 | 0.81/0.91 | Not FDA approved |
Bloom et al[33] | dd-cfDNA | PBL single gene sequencing | 102 (107 samples) | ABMR and I b or higher TCMR | 0.59/0.85 | 0.61/0.84 | FDA approved |
Acquino–Dias et al[64] | FOXP3 | PBL, urine (PCR) | 65 (78 sample) | AR vs DGF | 0.94/0.95 | 0.94/0.95 | |
Li et al[65] | Granzyme B, perforin | Urine mRNA (PCR) | 85 (151 samples) | AR | 0.79-0.83 /0.77-0.83 | - | |
Hricik et al[66] | Urine CXCL9 | Urine ELISA | 258 | TCMR | 0.85/0.81 | 0.68/0.92 | Not FDA approved |
Suthanthiran et al[67] | Urine 3 gene; CD3E, CXCL10, 18SrRna | Urine RNA by PCR | 485 pts (4300 samples) | Diagnosis AR 20 d early | 0.79/0.78 | - | Not FDA approved |
Renesto et al[68] | TIM-3 | PBL, urine mRNA PCR | 115 (160 samples) | Diagnose AR, values normal post treatment | 0.87/0.95 | 0.87/0.93 | |
Valujskikh et al[69] | miRNA-210 | Urine miR-210 PCR | 81 (88 samples) | Diagnose AR, values normal post treatment | 0.52/0.74 | - |
- Citation: Chopra B, Sureshkumar KK. Emerging role of cell-free DNA in kidney transplantation. World J Exp Med 2021; 11(5): 55-65
- URL: https://www.wjgnet.com/2220-315x/full/v11/i5/55.htm
- DOI: https://dx.doi.org/10.5493/wjem.v11.i5.55