Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate

doi:10.5493/wjem.v10.i1.1

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World Journal of Experimental Medicine

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Jan 8, 2020; 10(1): 1-9
Published online Jan 8, 2020. doi: 10.5493/wjem.v10.i1.1

Table 3 Percentage in median, minimum and maximum for transforming growth factor-β1 and bone morphogenetic protein-2 values in cells for chondroid zone

Chondroid layer	Day	TGF-b1		P value	BMP-2		P value
Chondroid layer	Day	Control	Alendronate	P value	Control	Alendronate	P value
Reserve	3	-	-	-	-	12 (10-14)	P < 0.001
Reserve	12	-	-	-	-	34 (30-36)	P < 0.001
Proliferative	3	23.01 (19-26)	16.27 (14-19)	P = 0.047	-	72.21 (70-75)	P < 0.001
Proliferative	12	19.12 (17-23)	2.33 (0-3)	P < 0.001	-	67.43 (66-69)	P < 0.001
Maturation	3	89.64 (85-93)	93.07 (91-94)	P = 0.673	-	88.61 (86-81)	P < 0.001
Maturation	12	83 (80-84)	1.06 (0-1)	P < 0.001	13 (12-15)	94.05 (92-98)	P < 0.001
Hipertrophic	3	96.35 (94-99)	97.66 (95-98)	P = 0.772	2 (2-3)	82.17 (80-85)	P < 0.001
Hipertrophic	12	93.52 (92-95)	92.31 (90-93)	P = 0.694	42 (41-44)	93.00 (90-95)	P = 0.027

For each same time period values P < 0.05 were considered statistically different.

Citation: Vieira JS, Cunha EJ, de Souza JF, Chaves LHK, de Souza JL, Giovanini AF. Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate. World J Exp Med 2020; 10(1): 1-9
URL: https://www.wjgnet.com/2220-315x/full/v10/i1/1.htm
DOI: https://dx.doi.org/10.5493/wjem.v10.i1.1