Copyright
©The Author(s) 2020.
World J Exp Med. Jan 8, 2020; 10(1): 1-9
Published online Jan 8, 2020. doi: 10.5493/wjem.v10.i1.1
Published online Jan 8, 2020. doi: 10.5493/wjem.v10.i1.1
Cartilage zone | Area accounted (mm2) | |||||
3rd day | 12th day | |||||
Control | Alendronate | P value | Control | Alendronate | P value | |
Reserve | 6.12 (5.52-6.51) | 5.63 (5.07-5.71) | P = 0.061 | 3.33 (3.22-3.51) | 2.26 (2.11-2.29) | P = 0.056 |
Proliferative | 4.02 (3.82-4.44) | 4.12 (3.98-4.58) | P = 0.071 | 3.38 (3.35-3.43) | 3.11 (3.05-3.26) | P = 0.061 |
Maturation | 0.4 (0.32-0.46) | 0.36 (0.29-0.40) | P = 0.073 | 0.27 (0.16-0.29) | 0.04 (0.01-0.06) | P = 0.002 |
Hipertrophic | 4.12 (3.66-4.31) | 7.59 (7.31-7.77) | P = 0.032 | 4.02 (3.96-4.26) | 2.17 (2.11-2.32) | P < 0.0001 |
- Citation: Vieira JS, Cunha EJ, de Souza JF, Chaves LHK, de Souza JL, Giovanini AF. Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate. World J Exp Med 2020; 10(1): 1-9
- URL: https://www.wjgnet.com/2220-315x/full/v10/i1/1.htm
- DOI: https://dx.doi.org/10.5493/wjem.v10.i1.1