Role of LIGHT in the pathogenesis of joint destruction in rheumatoid arthritis

Figure 2 LIGHT augments receptor-activator nuclear factor kappa-B ligand-induced osteoclastogenesis from rheumatoid arthritis synovial fluid macrophages. A: Dentine slice stained with Toluidine blue showing lacunar resorption pits in 14-d RA SF macrophage cultures incubated with M-CSF and sRANKL ± LIGHT; B: Percentage surface area lacunar resorption on dentine slices in 14-d RA SF macrophage cultures incubated with M-CSF and sRANKL ± LIGHT. Data is expressed as mean ± SEM of three independent experiments where each condition was carried out in triplicate; ^aP < 0.05. RANKL: Receptor-activator nuclear factor kappa-B ligand; RA: Rheumatoid arthritis; SF: Synovial fluid; M-CSF: Macrophage-colony stimulating factor.