Association of insulin resistance with serum ferritin and aminotransferases-iron hypothesis

Table 2 Comparison of serum indices of iron by the presence or absence of diabetes mellitus

	Non-Hispanic whites				Non-Hispanic blacks				Hispanics
	Male		Female		Male		Female		Male		Female
	DM	Non-DM	DM	Non-DM	DM	Non-DM	DM	Non-DM	DM	N0n-DM	DM	Non-DM
n	166	1207	137	1465	98	798	106	951	115	842	132	832
Iron (mcg/dL)
Mean	93	95	83	87	82	87	70	75	90	98	82	84
(95%CI)	(89, 97)	(94, 97)	(78, 88)	(86, 89)	(77, 87)	(85, 89)	(64, 75)	(74, 77)	(84, 97)	(96, 100)	(76, 87)	(82, 86)
P1	NS		NS		NS		NS		0.01		NS
P2	NS		NS		NS		NS		NS		NS
P3	NS		NS		NS		NS		NS		NS
Total iron binding capacity (mcg/dL)
Mean	351	344	359	360	333	334	342	353	353	354	362	377
(95%CI)	(343, 359)	(341, 346)	(350, 368)	(357, 363)	(322, 344)	(330, 337)	(331, 352)	(349, 356)	(343, 363)	(351, 358)	(351, 373)	(372, 381)
P1	NS		NS		NS		NS		NS		0.01
P2	0.002		NS		NS		NS		NS		NS
P3	NS		NS		NS		NS		NS		NS
Transferrin saturation (%)
Mean	27	28	23	25	25	26	21	22	26	28	23	23
(95%CI)	(26, 28)	(28, 29)	(22, 25)	(24, 25)	(23, 26)	(26, 27)	(19, 22)	(21, 22)	(24, 28)	(27, 28)	(22, 25)	(22, 23)
P1	NS		NS		NS		NS		0.03		NS
P2	NS		NS		NS		NS		NS		NS
P3	NS		NS		NS		NS		NS		NS
Ferritin (mcg/L)
Mean	228	169	152	84	282	206	167	86	230	150	138	56
(95%CI)	(200, 256)	(161, 177)	(129, 175)	(79, 89)	(237, 327)	(195, 218)	(139, 195)	(79, 92)	(190, 270)	(142, 159)	(104, 171)	(52, 60)
P1	< 0.000001		< 0.000001		0.00003		< 0.000001		< 0.000001		< 0.000001
P2	0.0001		0.000003		0.02		0.0001		0.00001		< 0.000001
P3	0.0002		0.000003		0.03		0.0001		0.000004		< 0.000001

Data presented mean with 95%CI. To convert values for iron and total iron binding capacity to mol/L, multiply by 0.1791.

¹P values for unadjusted comparison;

²P values for comparison after adjustment for age and body mass index;

³P values for comparison after adjustment for age, body mass index, alcohol consumption, and mineral/iron supplement. NS: Not significant (P > 0.05); DM: Diabetes mellitus; NDM: Non-diabetic mellitus.