Review
Copyright ©The Author(s) 2015.
World J Exp Med. May 20, 2015; 5(2): 84-102
Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.84
Table 1 Components of Wnt/β-catenin signaling deregulated in gastric cancer
Upregulation or function increase in gastric cancer
Wnt-1, Wnt-2, Wnt-2B, Wnt-5a, Wnt-6, Wnt-10A[47,69-75,232]
Fzd-3[78]
CTNNB1[9,88-93,96,97]
LRP6[228]
TCF7L2[98-100]
PPN[79]
CDH17[80]
EZH2[81]
HMGA1, HMGA2[210,211]
YY1[86]
TC1 (C8orf4)[201,202]
miR-17-92[161]
mir-10a[168]
has-miR-335[166]
hsa-miR-375[163]
Downregulation or function inhibition in gastric cancer
Downregulation by hypermethylationInactivation by miRNAs
APC[145,146]APC[175]
sFRP1, sFRP2, sFRP4, sFRP5[78,96,149]AXIN2[159]
WIF-1[144,149]EZF1[78]
Dkk-1, Dkk-2, Dkk-3[59,144,148,149]HIPK1[161]
NKD1[149]HSulf-1[168]
Sox10, Sox17[106,107,112,149]RUNX2[159]
HSulf-1[108]Inactivation by phosphorylation
RUNX3[147]GSK3β[105]
PRDM5[152,153]Inactivation by overexpression of EZH2
RASSF10[154]CXXC4[81]
OSR1[111,112]Other or undefined mechanisms
Inactivation by protein mislocalizationSox7[113]
RUNX3[147]RACK1[109]
Inactivation by H. pylori virulence factorZNRF3[110]
RNF138[226,227]CHD8[131]
Deletion or mutationPLA2G2A[205]
APC[92,104,133-137]has-miR-148a[165]
GSK3β[104]miR-193b[163]
β-TrCP[142]miR-200a[176,177]
AXIN1, AXIN2[90,91]