Copyright
©The Author(s) 2015.
World J Exp Med. May 20, 2015; 5(2): 84-102
Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.84
Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.84
Upregulation or function increase in gastric cancer | |
Wnt-1, Wnt-2, Wnt-2B, Wnt-5a, Wnt-6, Wnt-10A[47,69-75,232] | |
Fzd-3[78] | |
CTNNB1[9,88-93,96,97] | |
LRP6[228] | |
TCF7L2[98-100] | |
PPN[79] | |
CDH17[80] | |
EZH2[81] | |
HMGA1, HMGA2[210,211] | |
YY1[86] | |
TC1 (C8orf4)[201,202] | |
miR-17-92[161] | |
mir-10a[168] | |
has-miR-335[166] | |
hsa-miR-375[163] | |
Downregulation or function inhibition in gastric cancer | |
Downregulation by hypermethylation | Inactivation by miRNAs |
APC[145,146] | APC[175] |
sFRP1, sFRP2, sFRP4, sFRP5[78,96,149] | AXIN2[159] |
WIF-1[144,149] | EZF1[78] |
Dkk-1, Dkk-2, Dkk-3[59,144,148,149] | HIPK1[161] |
NKD1[149] | HSulf-1[168] |
Sox10, Sox17[106,107,112,149] | RUNX2[159] |
HSulf-1[108] | Inactivation by phosphorylation |
RUNX3[147] | GSK3β[105] |
PRDM5[152,153] | Inactivation by overexpression of EZH2 |
RASSF10[154] | CXXC4[81] |
OSR1[111,112] | Other or undefined mechanisms |
Inactivation by protein mislocalization | Sox7[113] |
RUNX3[147] | RACK1[109] |
Inactivation by H. pylori virulence factor | ZNRF3[110] |
RNF138[226,227] | CHD8[131] |
Deletion or mutation | PLA2G2A[205] |
APC[92,104,133-137] | has-miR-148a[165] |
GSK3β[104] | miR-193b[163] |
β-TrCP[142] | miR-200a[176,177] |
AXIN1, AXIN2[90,91] |
- Citation: Chiurillo MA. Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review. World J Exp Med 2015; 5(2): 84-102
- URL: https://www.wjgnet.com/2220-315X/full/v5/i2/84.htm
- DOI: https://dx.doi.org/10.5493/wjem.v5.i2.84