Wound healing reaction: A switch from gestation to senescence

Figure 7 Neurogenic and bone marrow-related axes coupled in the inflamed endothelial egg, after wound. The upregulated extra-embryonic functions, i.e., coelomic-amniotic or neurogenic, and trophoblastic-vitelline or bone marrow-related, are focused in the endothelial inflammatory egg, favoring the induction of a gastrulation-like phenotype, which evolves towards re-epithelization and fibrosis (scar) in post-natal life. NA: Neurogenic axis; AG: Adrenal gland; BMA: Bone marrow-related Axis; c: Coagulation; sc: Stem cell; mc: Mast cell. R: Regeneration; f: Fibrosis; l: Leukocytes; M: Microbiome. ve: Post-capillary venous endothelium; heve: High endothelial venular endothelium; le: Lymphatic endothelium; bce: Blood capillary endotelium; pcve: Psot capillary venous endothelium.