Wound healing reaction: A switch from gestation to senescence

Figure 2 First or immediate phase of the acute inflammatory response. On the left side, a schematic representation in which the tissue suffers the injury and therefore necrosis of the epithelial cells are produced. In turn, on the right side, the beginning of the tissue inflammatory response in response to necrosis is shown. This initial phase presents ischemia-reoxygenation and interstitial edema (E) with interstitial infiltration of mediators of the stress response as well as substrates including glucose, amino acids and lipids. In addition, the lymphatic circulation (L) is activated. A: Arterial microcirculation; V: Post-capillary venous circulation.