Wound healing reaction: A switch from gestation to senescence

Figure 1 Schematic representation of the different stages of wound repair. During the post-traumatic local inflammatory response three successive and overlapped phases: in the arterial side of the microcirculation (red), a nervous (N) or immediate phase with ischemia-reperfusion (I/R) occurs; in the post-capillary venule (blue), an immune (I) or intermediate phase with a leukocytic (L) phenotype is expressed; and, finally an endocrine (E) or late with an angiogenic (A) phenotype is developed, which implies the capillaries neoformation.