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©2012 Baishideng.
World J Exp Med. Jun 20, 2012; 2(3): 37-44
Published online Jun 20, 2012. doi: 10.5493/wjem.v2.i3.37
Published online Jun 20, 2012. doi: 10.5493/wjem.v2.i3.37
Table 1 Approximate threshold doses of conventionally fractionated therapeutic radiation for clinically detrimental nonstochastic effects in various tissues
Organ | Injury at 5 yr | Threshold dose (sv)1 | Irradiation field (area) |
Fetus | Death | 2 | Whole |
Bone marrow | Hypoplasia | 2 | Whole |
Ovary | Permanent sterility | 2-3 | Whole |
Lens | Cataract | 5 | Whole |
Testes | Permanent sterility | 5-15 | Whole |
Cartilage, child | Arrested growth | 10 | Whole |
Breast, child | Hypoplasia | 10 | 5 cm2 |
Bone, child | Arrested growth | 20 | 10 cm2 |
Bone marrow | Hypoplasia, fibrosis | 20 | Localized |
Muscle, child | Hypoplasia | 20-30 | Whole |
Kidney | Nephrosclerosis | 23 | Whole |
Lymph nodes | Atrophy | 33-45 | - |
Liver | Liver failure, ascites | 35 | Whole |
Lung | Pneumonitis, fibrosis | 40 | Lobe |
Heart | Pericarditis, pancarditis | 40 | Whole |
Stomach, small intestine, colon | Ulcer, perforation | 45 | 100 cm2 |
Thyroid | Hypothyroidism | 45 | Whole |
Pituitary | Hypopituitarism | 45 | Whole |
Lymphatics | Sclerosis | 50 | - |
Central nervous system (brain) | Necrosis | 50 | Whole |
Spinal cord | Necrosis, transection | 50 | 5 cm2 |
Salivary glands | Xerostomia | 50 | 50 cm2 |
Cornea | Keratitis | 50 | Whole |
Capillaries | Telangiectasis, fibrosis | 50-60 | - |
Breast, adult | Atrophy, necrosis | > 50 | Whole |
Rectum | Ulcer, stricture | 55 | 100 cm2 |
Skin | Ulcer, severe fibrosis | 55 | 100 cm2 |
Eye | Panophthalmitis, hemorrhage | 55 | Whole |
Oral mucosa | Ulcer, severe fibrosis | 60 | 50 cm2 |
Esophagus | Ulcer, stricture | 60 | 75 cm2 |
Cartilage, adult | Necrosis | 60 | Whole |
Urinary bladder | Ulcer, contracture | 60 | Whole |
Bone, adult | Necrosis, fracture | 60 | 10 cm2 |
Ear (inner) | Deafness | > 60 | Whole |
Adrenal | Hypoadrenalism | > 60 | Whole |
Vagina | Ulcer, fistula | 90 | 5 cm |
Muscle, adult | Atrophy | > 100 | Whole |
Uterus | Necrosis, perforation | > 100 | Whole |
- Citation: Rodgerson DO, Reidenberg BE, Harris AG, Pecora AL. Potential for a pluripotent adult stem cell treatment for acute radiation sickness. World J Exp Med 2012; 2(3): 37-44
- URL: https://www.wjgnet.com/2220-315X/full/v2/i3/37.htm
- DOI: https://dx.doi.org/10.5493/wjem.v2.i3.37