Altered expression of miR-125a and dysregulated cytokines in systemic lupus erythematosus: Unveiling diagnostic and prognostic markers

Figure 4 The prognostic utilities of microRNA-125a, tumor necrosis factor-alpha, and interleukin 12 to predict flare in systemic lupus erythematosus patients. Based on the optimal cut-off points obtained from receiver operating characteristic curve analyses, the levels of microRNA-125a (miR-125a), tumor necrosis factor-alpha (TNF-α), and interleukin 12 (IL-12) were categorized as low or high. The predictive ability of these biomarkers for the outcome (Flare) in systemic lupus erythematosus (SLE) patients was assessed using the log-rank test. A: The results showed that miR-125a was not significantly predictive of the outcome (P < 0.7151); B: TNF-α showed a potential for predicting the outcome, but the association was not statistically significant (P = 0.4828); C: In contrast, IL-12 demonstrated a significant predictive capability for the outcome in SLE patients (P = 0.0508) based on the log-rank test results.