Early anesthetic exposure and long-term cognitive impairment

Figure 1 N-methyl-D-aspartate receptor signaling and protein interactions mediated by PDZ domains of postsynaptic density-95 family proteins at postsynaptic density in the central nervous system. Through the first two PDZ domains (mainly PDZ2), postsynaptic density-95 (PSD-95) family proteins interact with N-methyl-D-aspartate (NMDA) receptor NR2 subunit and downstream molecule neuronal nitric oxide synthase to regulate NMDA receptor-mediated synaptic plasticity. PSD-95 PDZ3 domain-mediated PSD-95/neuroligin interaction at the postsynaptic site of synapses modulates the presynaptic release probability of glutamate vesicles in a retrograde manner.