A short perspective on gene therapy: Clinical experience on gene therapy of gliomablastoma multiforme

Figure 3 Sitimagene ceradenovec is an adenoviral vector based suicide gene therapy, which is injected into the wall of the tumor cavity of glioma patients, after the resection of the tumor. Mainly healthy cells will be transduced producing the HSV-tk and converting the pro-drug ganciclovir into ganciclovir monophosphate. The actual cytotoxic metabolite ganciclovir triphosphate is killing possible residual proliferating tumor cells.