Impact of high dose vitamin C on platelet function

Figure 7 Hi vitamin C, but not Lo vitamin C exposure, was associated with significant changes in the eicosanoid profile over time. Addition of Lo/Hi VitC did not affect the levels of the PUFA: AA (A), EPA (B) and DHA (C) in comparison to saline controls (n = 10/group). Addition of Hi VitC was associated with significantly higher levels of 11-HETE (D) on days 5 and 8 (n = 10/group, ^aP < 0.05); 12-HETE (E) on days 2, 5 and 8 (n = 10/group, ^aP < 0.05); and 15-HETE (F) on day 8 (n = 10/group, ^aP < 0.05). TXB2 (G) was also significantly higher in the Hi VitC group on days 5 and 8 (n = 10/group, ^aP < 0.05). In addition, PGE₂ levels (H) were significantly higher on days 2 and 8 in the Hi VitC group (n = 10/group, ^aP < 0.05). VitC: Vitamin C; PUFA: Polyunsaturated fatty acids; AA: Arachidonic acid; EPA: Eicosapentanoic acid; DHA: Docosahexanoic acid; TXB₂: Thromboxane B2; PGE₂: Prostaglandin E2.