Prevention of stress-related ulcer bleeding at the intensive care unit: Risks and benefits of stress ulcer prophylaxis

Table 1 Efficacy of proton pump inhibitor compared to histamine 2 receptor antagonists at the intensive care unit

Meta-analysis	n	Risk reduction (bleeding)	Risk reduction (mortality)
Alhazzani et al[2]	1720	RR = 0.36	RR = 1.01
		(95%CI: 0.19-0.67)	(95%CI: 0.83-1.24)
Pongprasobchai et al[59]	569	OR = 0.42	n/a
		(95%CI: 0.20-0.91)
Barkun et al[60]	1587	OR = 0.30	OR = 1.19
		(95%CI: 0.17-0.54)	(95%CI: 0.84-1.68)
Lin et al[61]	936	RD = 0.04	RD = 0.00
		(95%CI: 0.09-0.01)	(95%CI: 0.04-0.05)

n/a: Not assessed; n: Patients included in the meta-analysis; RR: Relative risk; OR: Odds ratio; PPI: Proton pump inhibitor(s); RD: Risk difference.